Anticonvulsant drug actions on GABA responses and sustained repetitive firing of neurons in cell culture
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چکیده
منابع مشابه
GABA and bicuculline actions on mouse spinal cord and cortical neurons in cell culture.
The neutral amino acid gamma-aminobutyric acid (GABA) produced membrane hyperpolarization and increased membrane chloride ion conductance of spinal cord (SC) and cortical (CTX) neurons in cell culture. GABA dose-response curves were obtained for SC neurons by pressure applying known concentrations of GABA from micropipettes with large tips (miniperfusion pipettes). GABA response threshold was a...
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The effects of arginine, homoarginine, alpha-keto-delta-guanidinovaleric acid and argininic acid (guanidino compounds that were found to be increased in hyperargininemia) were evaluated on responses to gamma-aminoburtyric acid (GABA) and glycine (Gly) on mouse neurons in primary dissociated cell culture. GABA and Gly were applied iontophoretically and intracellular microelectrode recording tech...
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ژورنال
عنوان ژورنال: Neuropharmacology
سال: 1984
ISSN: 0028-3908
DOI: 10.1016/0028-3908(84)90275-2